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A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection
Sponsor: Mayo Clinic
Summary
The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.
Official title: Role of the Neurovascular System in Spontaneous Coronary Artery Dissection (SCAD)
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2023-06-01
Completion Date
2027-08
Last Updated
2025-06-12
Healthy Volunteers
Yes
Interventions
Arterial Tonometry
We will measure arterial stiffness using arterial tonometry.
Echocardiogram
We will collect limited ultrasound images of the heart.
Carotid Ultrasounds
We will perform ultrasound imaging of the carotid artery.
Elastography
We will measure the elastic properties of the arteries using elastography.
Ankle-Brachial Index
We will measure the ankle-brachial index to assess peripheral artery blood flow.
Microneurography with sympathoexcitatory maneuvers
We will measure sympathetic nerve activity at rest and in response to isometric handgrip, mental stress test, cold pressor test, Valsalva maneuvers.
Locations (1)
Mayo Clinic Rochester
Rochester, Minnesota, United States