Clinical Research Directory

Inclusion Criteria: To be enrolled, the participant must meet the following inclusion criteria: 1. age 18 years or older 2. be patients of record at the University of Pittsburgh Periodontics Department 3. Systemically healthy patients 4. Full-mouth plaque score and full-mouth bleeding score ≤ 30% (measured at six sites per tooth) 5. Study individuals will be included if they met the following criteria: (a) one or more peri-implant sites with PPD ≥6 mm combined with BOP/suppuration, and (b) peri-implant marginal bone loss, defined as a crater like defect ≥3 mm as assessed from intra- oral radiographs, (c) Infrabony circumferential defect of more than 270° determined by CBCT, (d) crown not possible to retrieve before surgery Exclusion Criteria:study individuals will be excluded if any of the folllowing apply: 1. Unlikely to be able to comply with study procedures and unable to return to SDM for multiple appointments over the course of about a year. 2. Uncontrolled pathologic processes in the oral cavity (cancer and active periodontal disease) 3. History of allergic reactions to dental local anesthetics 4. History of head and neck chemotherapy or radiation within 5 years prior to surgery 5. Systemic or local disease or condition that could compromise post-operative healing and/or osseointegration, such as HIV infection, Paget's disease, osteoporosis, etc. 6. Reported diagnosis of diabetes mellitus 7. Patients taking corticosteroids, IV bisphosphonates, or any immunosuppressant medication that could influence post-operative healing and/or osseointegration 8. Smokes more than 10 cigarettes/day (self-reported) 9. History or current medications with known side effects of gingival growth (including any of the following: phenytoin, phenobarbital, lamotrigine, vigabatrin, ethosuximide, topiramate, primidone, nifedipine, diltazem, amlodipine, felodipine, verapamil, cyclosporine). 10. Present alcohol and/or drug abuser (self-reported) 11. Pregnant, unsure pregnancy status, or lactating females (self-reported), or planning to become pregnant within 1 year of study enrollment