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Fatigability in Long COVID-19
Sponsor: VA Office of Research and Development
Summary
The overall goal of this project is to advance the understanding of underlying mechanisms impacting performance fatigability and perceived fatigability in Veterans with post-COVID-19 fatigue and explore the safety and feasibility of a home-based "minimal-dose" resistance exercise program in this population. The central hypothesis is that declines in force capacity, skeletal muscle oxygen extraction, and affective responses to physical activity offer potential mechanisms through which fatigability is increased in Veterans with post-COVID-19 fatigue. Moreover, home-based resistance exercise delivered remotely may provide a safe and feasibility treatment option for targeting neuromuscular and neurobehavioral factors influencing fatigability severity in this population.
Official title: Fatigue and Fatigability in Veterans Following SARS-CoV-2 Infection
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
21
Start Date
2023-07-31
Completion Date
2026-03-31
Last Updated
2025-09-05
Healthy Volunteers
No
Conditions
Interventions
Minimal-Dose Home-Based Resistance Exercise
8-week home-based resistance exercise performed one day per week.
Locations (1)
Washington DC VA Medical Center, Washington, DC
Washington D.C., District of Columbia, United States