Clinical Research Directory

Inclusion Criteria: * Patient older than 18 years. * Definitive diagnosis of acute lithiasic cholecystitis according to the GP Tokyo 2018 criteria. * Surgical decision of inoperable patient (if one or more of the following criteria is met: age ≥80 years, American Society of Anesthesiology (ASA) III or more, Charlson Comorbidity Index \> 5 and/or Karnofsky \< 50 or decision of the patient not to have surgery. * Signature of the informed consent of the study Exclusion Criteria: * Operable acute cholecystitis. * Refusal of the patient to participate in the study. * Anatomy of the GI tract altered by previous hepatobiliary or upper GI surgery. * Ascites. * Inability to tolerate endoscopy sedation, perforation of the digestive tract, or other contraindication to endoscopy. * Patients with decompensated cirrhosis, portal hypertension and/or gastric varices * Coagulopathy with uncorrectable INR\>1.5 or thrombocytopenia \<50,000/mm3 uncorrectable. * Other diagnoses on admission (choledocholithiasis, liver abscesses, acute pancreatitis or biliopancreatic neoplasia). * Hemodynamic instability. * Baseline ECOG \>=4 * Survival expectancy \< 6 months