Clinical Research Directory

Substudy A: Group 1 to Group 10 Inclusion Criteria: 1. Male or female participants 50 through 69 years of age (inclusive) at the time of consent. 2. Healthy participants who are determined by clinical assessment, including medical history and clinical judgment of the investigator, to be eligible for inclusion in the study. Note: Known infection with HIV, HCV or HBV is an exclusion in Substudy A. 3. Participants who are willing and able to comply with all scheduled visits, investigational plan, laboratory tests, lifestyle considerations, and other study procedures. 4. Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the ICD and in this protocol Substudy A: Group 11 to Group 14 Inclusion Criteria: 1. Male or female participants 50 through 69 years of age (inclusive) at the time of consent. 2. Healthy participants who are determined by clinical assessment, including medical history and clinical judgment of the investigator, to be eligible for inclusion in the study. Note: Known infection with HIV, HCV or HBV is an exclusion in Substudy A. 3. Participants who are willing and able to comply with all scheduled visits, investigational plan, laboratory tests, lifestyle considerations, and other study procedures. 4. Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the ICD and in this protocol. 5. Has a body mass index (BMI) between 18 and 35 (inclusive) kg/m2 at the screening visit. Substudy A: Group 1 to Group 10 Exclusion Criteria: 1. History of HZ (shingles). 2. History of Guillain-Barré syndrome. 3. Known infection with HIV, HCV, or HBV. 4. History of severe adverse reaction associated with a vaccine and/or severe allergic reaction (eg, anaphylaxis) to any component of the study intervention(s). 5. Immunocompromised individuals with known or suspected immunodeficiency, as determined by history and/or laboratory/physical examination. 6. Bleeding diathesis or condition associated with prolonged bleeding that would, in the opinion of the investigator, contraindicate intramuscular injection. 7. Other medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study. 8. Women who are pregnant or breastfeeding. 9. Prior history of heart disease (eg, heart failure, recent coronary artery disease, cardiomyopathies, pericarditis/myocarditis). 10. Previous vaccination with any varicella or HZ vaccine. 11. Individuals who receive treatment with immunosuppressive therapy, including cytotoxic agents or systemic corticosteroids, eg, for cancer or an autoimmune disease, or planned receipt throughout the study. 12. Receipt of blood/plasma products or immunoglobulin, from 60 days before study intervention administration or planned receipt throughout the study. 13. Any participant who has received or plans to receive an RNA vaccine 28 days prior to Vaccination 1. 14. Participation in other interventional studies within 28 days prior to study entry or anticipated involvement through and including 6 months after the last dose of study intervention. Participation in observational studies is permitted. 15. Any screening hematology and/or blood chemistry laboratory value that meets the definition of a ≥ Grade 1 abnormality; or any abnormal bilirubin or troponin I value. 16. Screening 12-lead ECG that, as judged by the investigator, is consistent with probable or possible myocarditis/pericarditis or demonstrates clinically relevant abnormalities that may affect participant safety or interpretation of study results. 17. Participation or planned participation in strenuous or endurance exercise within 7 days before or after each study intervention administration. 18. Investigator site staff directly involved in the conduct of the study and their family members, site staff otherwise supervised by the investigator, and sponsor and sponsor delegate employees directly involved in the conduct of the study and their family members. SubStudy B: Inclusion Criteria: 1. Male or female participants 50 through 85 years of age (inclusive) at the time of consent. 2. Healthy participants who are determined by clinical assessment, including medical history and clinical judgment of the investigator, to be eligible for inclusion in the study. 3. Participants who are willing and able to comply with all scheduled visits, investigational plan, laboratory tests, lifestyle considerations, and other study procedures. 4. Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the ICD and in this protocol. 5. Has a BMI between 18 and 35 (inclusive) kg/m2 at the screening visit. Exclusion Criteria: 1. History of HZ (shingles). 2. History of Guillain-Barré syndrome. 3. History of severe adverse reaction associated with a vaccine and/or severe allergic reaction (eg, anaphylaxis) to any component of the study intervention(s). 4. Immunocompromised individuals with known or suspected immunodeficiency, as determined by history and/or laboratory/physical examination. 5. Bleeding diathesis or condition associated with prolonged bleeding that would, in the opinion of the investigator, contraindicate intramuscular injection. 6. Other medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study. 7. Women who are pregnant or breastfeeding. 8. Prior history of heart disease (eg, heart failure, recent coronary artery disease, cardiomyopathies, pericarditis, or myocarditis). 9. Previous vaccination with any varicella or HZ vaccine. 10. Individuals who receive treatment with immunosuppressive therapy, including cytotoxic agents or systemic corticosteroids, eg, for cancer or an autoimmune disease, or planned receipt throughout the study. 11. Receipt of blood/plasma products or immunoglobulin, from 60 days before study intervention administration or planned receipt throughout the study. 12. Any participant who has received or plans to receive an RNA vaccine 28 days prior to Vaccination 1. 13. Participation in other interventional studies within 28 days prior to study entry or anticipated involvement through and including 6 months after the last dose of study intervention is prohibited. Participation in observational studies is permitted. 14. Investigator site staff directly involved in the conduct of the study and their family members, site staff otherwise supervised by the investigator, and sponsor and sponsor delegate employees directly involved in the conduct of the study and their family members.