Clinical Research Directory

Inclusion Criteria: * Both Male and female patients * Ages between 18-75 years of age * Individual is competent and willing to provide written, informed consent to participate in this clinical study with either * CKD stage 3a/b or * ESRD on stable renal replacement therapy or * Mild to moderate heart failure with reduced ejection fraction Exclusion Criteria: * Ineligible anatomy * Prior treatment with other devices for hypertension including but not limited to ROX Coupler (ROX Medical) , Mobius stent, and/or the CVRx (CVRx Inc) barostimulator device. * Individual has experienced a myocardial infarction, unstable angina, or a cerebrovascular accident within 3 months of the screening visit. * Documented history of chronic active inflammatory bowel disorders such as Crohn's disease or ulcerative colitis. * Individual has clinically significant cardiac structural valvular disease, unless corrected by a properly functional prosthetic valve * Individual has been admitted for inpatient hospitalization for decompensated HF in the previous month * Female participants of childbearing potential must have a negative pregnancy test prior to treatment. * Individual has a known, unresolved history of drug use or alcohol dependency, lacks the ability to comprehend or follow instructions, or would be unlikely or unable to comply with study follow-up requirements. * Individual is currently enrolled in another investigational drug or device trial. Note: For the purpose of this protocol, participants involved in extended follow-up trials for products that were investigational but are currently commercially available are not considered enrolled in an investigational trial. * Individual has a disease or condition (aside from CKD, ESRD, and HFrEF) that may limit their life expectancy to \< 1 year.