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Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease
Sponsor: Central Denmark Region
Summary
The STOP-COPD trial is a randomized, patient-blinded, prehospital clinical trial designed to evaluate the effect of titrated oxygen therapy compared to standard oxygen treatment in patients with suspected acute exacerbation of chronic obstructive pulmonary disease (AECOPD) treated with inhaled bronchodilators. The primary objective is to determine whether a titrated oxygen strategy targeting SpO₂ 88-92% can reduce 30-day mortality compared to the current standard practice using 100% compressed oxygen as a nebulizer driver.
Key Details
Gender
All
Age Range
40 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1888
Start Date
2025-06-02
Completion Date
2028-05-31
Last Updated
2025-06-10
Healthy Volunteers
No
Conditions
Interventions
Titrated Oxygen
Titrated oxygen strategy - a mix of supplemental oxygen and compressed atmospheric air as driver for inhaled bronchodilators to target SpO2 88-92%
Standard Oxygen
Standard care using compressed oxygen (100%) as driver for inhaled bronchodilators
Locations (1)
Prehospital Emergency Medical Servises, Central Denmark Region
Aarhus N, Denmark