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The UPDATE Trial (Uvb Phototherapy in Dermatology for ATopic Eczema)
Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Summary
The goal of this randomized controlled trial is to study the (cost)effectiveness of NB-UVB phototherapy in patients with atopic eczema/atopic dermatitis. Half of the participants will undergo a course of NB-UVB phototherapy of 8-16 weeks and apply optimal topical therapy (OTT) for a minimum of 3 months. Researchers will compare the outcomes of this group with the other half of participants that apply OTT only.
Official title: The UPDATE Trial (Uvb Phototherapy in Dermatology for ATopic Eczema): A Multicenter Randomized Controlled Trial of Narrowband UVB Versus Optimized Topical Therapy in Patients With Atopic Eczema
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
316
Start Date
2023-02-22
Completion Date
2026-12
Last Updated
2026-01-23
Healthy Volunteers
No
Interventions
NB-UVB phototherapy
Narrowband ultraviolet B irradiation 3 times a week
Optimal topical therapy
A combination of detailed instructions about the disease and treatments by trained nurses, bathing and washing advices, adequate emollients use, avoidance of triggers (including possible and proven contact allergens), fingertip unit explanation for active topical therapy, and personalized topical therapy with different potency topical steroids, calcineurin inhibitors and tar ointments
Locations (16)
Flevoziekenhuis
Almere Stad, Flevoland, Netherlands
Jeroen Bosch Ziekenhuis
's-Hertogenbosch, North Brabant, Netherlands
Centrum Oosterwal
Alkmaar, North Holland, Netherlands
OLVG
Amsterdam, North Holland, Netherlands
Amsterdam Universitair Medische Centra
Amsterdam, North Holland, Netherlands
Huid Medisch Centrum
Amsterdam, North Holland, Netherlands
Bergman Clinics
Haarlem, North Holland, Netherlands
Spaarne Gasthuis
Hoofddorp, North Holland, Netherlands
Dijklander Ziekenhuis
Purmerend, North Holland, Netherlands
Isala Klinieken
Zwolle, Overijssel, Netherlands
Medisch Centrum Leeuwarden
Leeuwarden, Provincie Friesland, Netherlands
Reinier de Graaf Gasthuis
Delft, South Holland, Netherlands
Leids Universitair Medisch Centrum
Leiden, South Holland, Netherlands
Alrijne Ziekenhuis
Leiderdorp, South Holland, Netherlands
Erasmus Medisch Centrum
Rotterdam, South Holland, Netherlands
Meander Medisch Centrum
Amersfoort, Utrecht, Netherlands