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Spinal Anaesthesia vs. General Anaesthesia for THA, TKA and UKA
Sponsor: Anders Troelsen
Summary
The goal of this randomized clinical trial is to investigate the postoperative recovery following hip and knee arthroplasty procedures depending on the use of either spinal anaesthesia (SA) or general anaesthesia (GA). The main questions are: * Are more patients able to be safely mobilized within 6 hours postoperatively when using GA compared to SA? * Does postoperative pain, nausea and vomiting, dizzyness, occurence of delirium and urinary retention differ between the anaesthetic methods? Participants, scheduled for total hip, total knee and unicomartmental knee arthroplasty, will be randomized to recieve spinal anaesthesia or general anaesthesia in relation to surgery. At 6 hours postoperatively a physiotherapist will conduct a 5-meter walking test to evaluate whether the participant can be safely mobilized.
Official title: Randomized Trial on Spinal Anaesthesia vs. General Anaesthesia (SAGA) on Recovery After Total Hip, Total Knee, and Unicompartmental Knee Arthroplasty
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
222
Start Date
2023-03-06
Completion Date
2025-04-06
Last Updated
2026-09-18
Healthy Volunteers
No
Conditions
Interventions
Spinal anesthesia
plain or heavy Bupivacaine hydrochloride 10 mg (2 mL) injected in the spinal canal
General anaesthesia
Propofol (induction: 1.0-2.0 mg/kg. infusion: 3-5 mg/kg/hour) + Remifentanil (induction: 3-5 mcg/kg, infusion: 0.5 mcg/kg/min) given intravenously
Locations (2)
Christian Bredgaard Jensen
Hvidovre, Denmark
Vejle Hospital
Vejle, Denmark