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Dexmetomedine for Post Operative Delirium in Elderly Patients Undergoing Elective Total Knee Replacement Under Spinal Anesthesia
Sponsor: Menoufia University
Summary
Postoperative delirium is a geriatric syndrome occurring after anesthesia and surgery which manifests as acute alterations in mental status, involving changes in cognition, attention, and levels of consciousness that tend to fluctuate The use of dexmedetomidine with the intention to prevent postoperative delirium remains controversial. Where it has shown to be effective in older adult patients undergoing cardiovascular and non-cardiovascular surgeries
Official title: Effect of Different Doses of Dexmedetomidine on Postoperative Delirium in Elderly Patients Undergoing Elective Total Knee Arthroplasty Under Spinal Anesthesia: A Pilot Randomized Controlled Trial
Key Details
Gender
All
Age Range
65 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
45
Start Date
2023-06-01
Completion Date
2024-02-20
Last Updated
2026-08-25
Healthy Volunteers
Yes
Conditions
Interventions
dexmetomedine infusion
50 ml mixture of saline 49 ml and dexmedetomidine 100 μg,
Dexmetomedine infusion
50 ml mixture of saline 48 ml and dexmedetomidine 200 μg
Placebo
Normal saline infusion
Locations (1)
Menoufia University
Menoufia, Menoufia, Egypt