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The Effectiveness of Adding Braun Anastomosis to Standard Child Reconstruction After Pancreatoduodenectomy
Sponsor: Radboud University Medical Center
Summary
The goal of this clinical trial (REMBRANDT) is to evaluate the effectiveness of adding an extra connection (i.e. 'Braun anastomosis') after standard reconstruction in pancreatic head resection in reducing the incidence of delayed gastric emptying.
Official title: The Effectiveness of Adding Braun Anastomosis to Standard Child Reconstruction to Reduce Delayed Gastric Emptying After Pancreatoduodenectomy (REMBRANDT): a Multicenter Randomized-controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
256
Start Date
2023-04-17
Completion Date
2025-09
Last Updated
2024-04-11
Healthy Volunteers
No
Interventions
Braun anastomosis
Participants will undergo open pancreatoduodenectomy (PD). The reconstruction technique will not be standardized. In addition to the reconstruction technique used, a side-to-side anastomosis will be created between the afferent and efferent jejunal limbs of the gastrojejunostomy (GJ) at 20 cm distance from the GJ. The anastomosis will be hand-sewn with monofilament PDS 3-0 one-layer running suture.
Standard Child reconstruction
Participants will undergo open pancreatoduodenectomy (PD). The reconstruction technique will not be standardized. The surgeon is able to perform the PD as normally would be done (antecolic, retrocolic, pylorus-preserving or with distal gastric resecting).
Locations (12)
Amsterdam UMC
Amsterdam, Netherlands
OLVG
Amsterdam, Netherlands
Catharina hospital
Eindhoven, Netherlands
Medical spectrum Twente
Enschede, Netherlands
Groningen UMC
Groningen, Netherlands
Medical center Leeuwarden
Leeuwarden, Netherlands
LUMC
Leiden, Netherlands
Maastricht UMC+
Maastricht, Netherlands
St Antonius hospital
Nieuwegein, Netherlands
Radboud UMC
Nijmegen, Netherlands
Erasmus MC
Rotterdam, Netherlands
Isala hospital
Zwolle, Netherlands