Clinical Research Directory

Inclusion Criteria: * Age 18 - 35 years * Standard weight-bearing AP and skyline view knee x-rays * Retropatellar or peripatellar knee pain for a minimum of 2 months * Confirmed diagnosis of AKP that has failed to improve with a minimum of 6 weeks of conservative treatment (activity modification, supervised physiotherapy, exercise therapy, taping or bracing, NSAIDS) * Pain aggravated by at least two of the following patellofemoral joint loading activities: squatting, running, ascending or descending stairs, or sitting with prolonged knee flexion. Exclusion Criteria: * X-ray evidence of knee osteoarthritis or fracture * Meniscal or ligamentous injury assessed or suspected on clinical examination * Previous knee surgery * History of patellar instability * Any contraindication to knee injection (overlying skin condition, joint infection, significant joint effusion, coagulopathy, previous adverse reaction, etc.) * Known allergy to Cingal™ or its constituents * Previous knee injection within the last 3 months * BMI greater than 30 kg/m2 * Diabetes, inflammatory conditions (rheumatologic disease, ankylosing spondylitis), or concurrent medical conditions which may result in chronic pain or altered pain sensation * Pregnant or breastfeeding * Workers Compensation Board case * Patient involved in litigation