Clinical Research Directory

Inclusion Criteria: * Patients ≥ 18 years old * Histologically confirmed diagnosis of squamous cell carcinoma of the oropharynx, p16-positive on immunohistochemistry or HPV-positive by In-Situ Hybridization * Pathologic T0 (unknown primary), T1, T2, or T3 disease (per AJCC 8th Ed) * Pathologic N0-N1 disease (per AJCC 8th Ed) * Preoperative plasma ctHPVDNA of ≥ 50 copies/mL * Undetectable postoperative plasma ctHPVDNA * ECOG Performance Status 0-1 Exclusion Criteria: * Prior external beam radiation therapy to the head and neck * Presence of T4 disease * ≥ 5 positive lymph nodes (which is pathologic N2 disease, per AJCC 8th edition) * Presence of distant metastatic disease * Uncontrolled inter-current illness including, but not limited to, symptomatic congestive heart failure, unstable angina pectoris, connective tissue disease or psychiatric illness/social situations that would limit compliance with study requirements.