Clinical Research Directory

Inclusion Criteria: * In accordance with the diagnostic criteria of Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2018 * Patients who have had a clinically significant ischemic stroke for the first time and are currently stable * Unilateral internal carotid artery or middle cerebral artery was confirmed for the first time as moderate to severe stenosis (≥50%) or occlusion on digital subtraction angiography examination （DSA）. * Did not receive surgical treatment such as balloon dilation * National Institute of Health stroke scale (NIHSS) score ≤3 * The clinical data is completed and be able to consistently complete the study * Age 18-80, education level≥ 6 years and agree to sign informed consent Exclusion Criteria: * Progressive stroke * Diseases with severe damage to other organs * Moderate to severe aortic insufficiency * Dissection aneurysm, aortic aneurysm, cerebral aneurysm * Significant pulmonary hypertension * Various bleeding disorders, bleeding tendencies, or use of anticoagulants, Prothrombin international normalized ratio （INR） \>2.0 * Active phlebitis, venous embolism, venous thrombosis of lower extremity * The presence of infection in the body * Valvular disease, congenital heart disease, cardiomyopathy * Uncontrolled hypertension (\>170/110mmHg) * Uncontrolled arrhythmia * Left heart failure * Pregnancy * Patients with cardiac pacemakers * Patients with arterial clamp after craniocerebral operation * Patients with metal implants, such as metal joints, shrapnel and orbital foreign bodies * History of moderate to severe cognitive impairment or psychiatric disorders * History of malignancy * moyamoya patients * Lower extremity arterial thrombosis