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Early Blocking Strategy for Metachronous Liver Metastasis of Colorectal Cancer Based on Pre-hepatic CTC Detection
Sponsor: Liaoning Cancer Hospital & Institute
Summary
In this study, the Quintuple method was applied for early intervention of prehepatic CTC-positive bowel cancer patients without dominant liver metastasis, aiming to explore the blocking effect of the Quintuple method on the metachronous liver metastases of colorectal cancer. A one-arm randomized clinical trial was conducted, and the patients were grouped according to their treatment methods. The patients with metachronous liver metastases were used as the end point of the experiment to evaluate the blocking effect of quintuple therapy.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2023-03-01
Completion Date
2026-09-01
Last Updated
2023-02-09
Healthy Volunteers
No
Interventions
Oxaliplatin
Oxaliplatin via intravenous drip on d1 at a dose of 130mg/m2 × patient 's body surface area
S1
Orally on d2-d15 at 20 mg three times daily
Cetuximab
Cetuximab combined with chemotherapy was administered simultaneously, once every three weeks,and intravenous drip was performed before oxaliplatin at a dose of 250 mg/m2 × body surface area.
Metronidazole
Metronidazole 0.4g/time, qd
Vitamin A
Vitamin A 25,000 units/time, qd
Folic acid
Folic acid 0.4 mg/time, qd
Capecitabine
Capecitabine via orally on d2-d15 two times daily at a dose of 1000mg/m2 × patient 's body surface area.