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Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
Sponsor: University of Texas Southwestern Medical Center
Summary
The overall purpose of this study is to investigate whether pulmonary limitations that increase the oxygen (O2) cost of breathing impact dyspnea on exertion (DOE) and peak exercise capacity in patients with HFpEF and obesity. As per investigator's hypothesis, obesity is likely a significant contributor to DOE and exercise intolerance in patients with HFpEF.
Official title: Targeting Breathing Limitations to Improve Functional Outcomes in Heart Failure With Preserved Ejection Fraction (HFpEF)
Key Details
Gender
All
Age Range
55 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
78
Start Date
2023-07-01
Completion Date
2029-06-30
Last Updated
2025-04-27
Healthy Volunteers
Yes
Interventions
HeO2 gas mixture
Low-density helium-oxygen gas mixture (HeO2: 21% O2 and 79% He). Participant will be breathing this gas mixture.
Room air gas mixture
Normal room air
Locations (1)
UT Southwestern Medical Center
Dallas, Texas, United States