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RECRUITING
NCT05724810
NA

Deep rTMS Modulating Insula Synaptic Density and Smoking Behavior in Schizophrenia

Sponsor: Stony Brook University

View on ClinicalTrials.gov

Summary

Purpose of the study: Evaluate the effect of deep repetitive transcranial magnetic stimulation (deep rTMS; hereafter abbreviated as "dTMS") on synaptic density measured with positron emission tomography (PET) and the radiotracer \[11C\]UCB-J. The investigators also seek to link plasticity changes in the regions targeted by the electric field (especially, the insula) to changes in the functioning of insula circuits and behavioral cigarette usage in patients with schizophrenia (SCZ). Importance of the study: This is the first study designed to directly evaluate the mechanism of action (MOA) of dTMS for smoking disruption in patients with SCZ. Patients with SCZ are a vulnerable population in high, immediate need of new smoking therapeutics for reducing premature morbidity and mortality.

Key Details

Gender

All

Age Range

18 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

38

Start Date

2023-04-04

Completion Date

2028-08-31

Last Updated

2024-04-25

Healthy Volunteers

No

Interventions

DEVICE

Active deep transcranial magnetic stimulation (dTMS)

First, the investigators will find the position of the right abductor pollicis brevis (APB) motor cortex, finding the minimal motor threshold (MT) required for its activation, which determines the strength of the pulses. After determining the MT, dTMS stimulation is applied 6 cm anterior to the motor "hot spot", at 120% of the MT. The target threshold is built toward gradually. During the first treatment, participants receive stimulation at 100% of the MT. During the second treatment, stimulation intensity increases to 110% of the MT. Beginning at the third treatment and continuing onward, participants receive treatment at 120% of the MT for the course of the treatment.

DEVICE

Sham dTMS

Sham group will go through the same procedure. The only difference is that the sham card does not deliver stimulation.

Locations (1)

Stony Brook University

Stony Brook, New York, United States