Inclusion Criteria for UT recipient:
* Patient aged 18 to 40 at the time of the UT;
* BMI (Body Mass Index) ≤ 30 kg/m²;
* With AUFI (type 1 or 2 MRKH syndrome and hysterectomy);
* Informed about the possibility of adoption;
* Compatibility with the donor (ABO group, Human Leukocyte Antigen (HLA) typing);
* Up-to-date vaccinations;
* Able to reach the transplant center in less than 11 hours (applicable only for the "deceased donor" arm);
* Having a parental project that is formulated by a heterosexual couple, by a couple of women or by a single woman;
* Vaginal cup of length greater than or equal to 7 cm.
Inclusion Criteria for a deceased brain-dead uterus donor:
* Any person who is brain dead and who has been duly diagnosed with the following criteria: Female gender;Age ≤ 42 years;Compatibility with the recipient (ABO group, HLA typing).
Inclusion Criteria for a live uterus donor:
* Patient belonging to the family of the recipient (mother, sister, aunt, mother-in-law...) or any person who can prove a stable emotional relationship for more than 2 years with the recipient (paragraphs 1 and 2 of Article L.1231-1 of the Public Health Code);
* Age ≥ 37 years and ≤ 62 years ;
* BMI ≤ 30 kg/m²;
* Having completed all her parenthood plans and no longer having any plans of pregnancy;
* Having had at least one live-born child at term (i.e. after 37 weeks of of amenorrhea);
* Compatibility with the recipient (ABO group, HLA typing);
* Normal suprapubic and/or endovaginal ultrasound or pelvic Magnetic Resonance Imaging (MRI), including uterine (no uterine abnormalities);
* Satisfactory uterine vessels assessed by MRI angio.
Exclusion Criteria for UT recipient:
* Patient with acquired uterine infertility and having had one or more children;
* Non-stable psychological state defined by a clinical psychologist after a qualitative interview;
* Severe co-morbidity;
* Association of severe abnormality with MRKH syndrome other than renal such as a cardiac malformation;
* A single pelvic kidney (urinary malformation that can be associated with MRKH syndrome);
* Pathogenic parental genetic anomaly which may lead to medical termination of pregnancy in the current state of knowledge;
* Diabetes (HbA1c \> 6%);
* Disorders of hemostasis: Prothrombin rate \<70%;
* Hemoglobin abnormality;
* Existence of hypertension;
* Vaginal reconstruction (neovagina) by digestive segment (colonic plastic surgery or other);
* History of major abdominal or pelvic surgery;
* Known thrombophilia (acquired or constitutional);
* HIV (Human Immunodeficiency Virus), HCV (Hepatitis C Virus), HBV (Hepatitis B Virus), HAV (Hepatitis A Virus), HTLV (Human T-Lymphotropic Virus) serology positive and presence of irreversible communicable infectious diseases;
* Positive vaginal hPV-HR (human Papilloma Virus High Risk) test;
* Signs of chronic renal disease;
* Drug addiction or alcoholism not weaned for more than 2 years or drug addiction or excessive alcohol consumption (\> 30 g/day of alcohol) current;
* History of cancer less than 10 years old, cancer under treatment (except in the cancer in situ, or basal cell skin lesion) or diagnosed during the selection process;
* History of pelvic radiotherapy or vaginal brachytherapy regardless of when this irradiation was performed;
* Known psychiatric pathology;
* Active tuberculosis (i.e. under treatment);
* Known or suspected contraindications to one or more of the treatments (active substance or excipient(s)) to be administered for the purposes of the study and/or essential treatment having an interaction/impact with one of the treatments planned by the research;
* Existence of organ dysfunction not compatible with the uterine transplantation protocol;
* History of smoking (defined as consumption greater than 20 packs/year) not weaned for more than 2 years or active smoker.
Exclusion Criteria for a deceased brain-dead uterus donor:
* Initial circulatory arrest of more than 10 minutes;
* Opposition to organ donation (register of refusals) or to uterine removal by a relative of the deceased;
* Chronic and uncontrolled hypertension;
* Absence of uterus (history of hysterectomy or uterine agenesis);
* Presence of uterine pathology;
* Delivery less than 6 months ago or ongoing pregnancy;
* History of several caesarean sections (multi-scarred uterus: more than 2);
* History of major abdominal or pelvic surgery;
* Infection of the sepsis type or uncontrolled infection (bacterial, viral viral, parasitic fungal, active Chagas disease);
* Encephalitis of viral origin or febrile of uncertain origin or meningoencephalitis of unknown origin;
* Risk of Prion disease transmission;
* Presence of an infectious disease: HIV, HCV, HBV, HTLV and presence of irreversible communicable infectious diseases;
* Carrying of human Papilloma Virus High Risk (hPV-HR) class 1 positive in the genital tract if known before transplantation;
* Positive EBV (Epstein-Barr Virus) serology in the donor if the recipient is EBV negative for EBV ;
* Positive pre-transplant virtual crossmatch;
* Donor/recipient ABO final check in the operating room before transplantation positive;
* Drug addiction or alcoholism not weaned for more than 2 years or drug addiction or excessive alcohol consumption (\> 30 g/day of alcohol) current;
* History of cancer less than 5 years old, cancer under treatment (except in the cancer in situ, or basal cell skin lesion) ;
* Active tuberculosis (i.e. under treatment);
* History of smoking (defined as consumption greater than 20 packs/year) not weaned for more than 2 years or active smoker.
Exclusion Criteria for a live uterus donor:
* Non-stable psychological state defined by a clinical psychologist clinician after a qualitative interview;
* Severe co-morbidity;
* Diabetes (HbA1c \> 6%);
* Hemostasis disorders: Prothrombin rate \<70%;
* Hemoglobin abnormality;
* hypertension treated with more than 2 antihypertensive drugs;
* Delivery less than 6 months ago or ongoing pregnancy;
* History of cervical pathology;
* History of recurrent miscarriage syndrome (defined as 3 consecutive consecutive miscarriages);
* History of premature delivery before 36 weeks of amenorrhea;
* History of pre-eclampsia;
* History of caesarean sections;
* History of major uterine surgery;
* History of major abdominal or pelvic surgery;
* Endometrial biopsy and diagnostic hysteroscopy showing an abnormality of the endometrium;
* Known thrombophilia (acquired or constitutional);
* HIV, HCV, HBV, HTLV serology positive and presence of irreversible communicable infectious diseases;
* Positive vaginal hPV-HR (human Papilloma Virus High Risk) test;
* PCR (Polymerase Chain reaction) on HSV (Herpes Simplex Virus) 1/2 positive sample;
* Abnormal vaginal swab;
* Signs of chronic kidney disease;
* Risks of Prion disease transmission;
* Drug addiction or alcoholism not weaned for more than 2 years or drug addiction or excessive alcohol consumption (\> 30 g/day of alcohol) current;
* History of cancer less than 10 years old, cancer under treatment (except in the cancer in situ, or basal cell skin lesion) or diagnosed during the selection process;
* History of pelvic radiotherapy or vaginal brachytherapy regardless of when this irradiation was performed;
* Known psychiatric pathology;
* Active tuberculosis (i.e. under treatment);
* Presence of a known thromboembolic risk factor;
* Angio-MRI, CT angiography and/or arteriography revealing an anomaly incompatible with uterine transplantation;
* History of smoking (defined as consumption greater than 20 packs/year) not weaned for more than 2 years or active smoker.
