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Volatilomic Approaches for the Study of CFTR Modulators (VOLATIL-CF)
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
This study relies on the hypotheses that (1) exhaled breath is intimately correlated to the patient's lung condition and that (2)the composition of exhaled breath , i.e. the VOCs profile, will be significantly modified from the first days of treatment by CFTR modulators in a or pauci/symptomatic patients such as young children under 12 years old. The non-invasive and longitudinal collection and analysis of exhaled breath may reveal modifications in signaling pathways impacted by these treatments on the very short term. This study is a single-center pilot study.
Official title: Volatilomic Approaches for the Study of CFTR Modulators
Key Details
Gender
All
Age Range
2 Years - Any
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2023-02-06
Completion Date
2024-07-04
Last Updated
2026-07-01
Healthy Volunteers
Not specified
Conditions
Interventions
exhaled breath collection
Fasting children will be asked to breathe normally through a mouthpiece for the collection and analysis of exhaled breath.
Data collection
Clinical data will be collected in order to seek correlations with the exhaled breath profile.
Locations (1)
Hôpital Necker - Enfants malades
Paris, Île-de-France Region, France