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Risk Factors for Type 2 Diabetes Mellitus With Cognitive Impairment: a Cohort Study
Sponsor: Peking University
Summary
The aim of this study was to analyze the risk factors for the development of type 2 diabetes mellitus (T2DM) with mild cognitive impairment (MCI) and its pathogenesis associated with gut microbiota. A prospective cohort study was conducted to recruit 3820 participants aged 45 years and above who attended health checkups at the checkup center of Linyi City People's Hospital, Shandong Province. A follow-up survey was conducted identifying whether the participant had T2DM as an exposure factor group. Socio-demographic characteristics, blood, urine, and stool samples, lifestyle surveys, dietary status, and neuropsychological tests were collected at baseline and follow-up, exploring the association between clinical characteristics and gut microbiota and the risk for the development of T2DM with MCI.
Key Details
Gender
All
Age Range
45 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
3820
Start Date
2017-01-01
Completion Date
2032-01-01
Last Updated
2023-02-15
Healthy Volunteers
Not specified
Interventions
whether the participants had T2DM
whether the participants had T2DM