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REmimazolam vs Propofol Total Intravenous Anesthesia on Outcomes After Major Noncardiac SurgEry
Sponsor: Nanfang Hospital, Southern Medical University
Summary
The goal of this randomized controlled trial is to compare total intravenous anesthesia with remimazolam vs total intravenous anesthesia with propofol in moderate-to-high risk patients undergoing major elective noncardiac surgery under general anesthesia. The primary hypothesis is that total intravenous anesthesia with remimazolam can increase days alive and out of hospital at postoperative day 30 compared with total intravenous anesthesia with propofol.
Official title: REmimazolam vs Propofol Total Intravenous Anesthesia on Outcomes After Major Noncardiac SurgEry (REPOSE-2): A Multicenter Randomized Controlled Trial
Key Details
Gender
All
Age Range
45 Years - Any
Study Type
INTERVENTIONAL
Enrollment
7188
Start Date
2023-04-03
Completion Date
2027-12-31
Last Updated
2025-08-26
Healthy Volunteers
No
Conditions
Interventions
Remimazolam
Remimazolam is administered intravenously for induction and maintenance of general anesthesia.
Propofol
Propofol is administered intravenously for induction and maintenance of general anesthesia.
Locations (44)
The First Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China
Huainanchaoyang Hospital
Huainan, Anhui, China
Suzhou First People's Hospital
Suzhou, Anhui, China
Beijing Chaoyang Hospital, Capital Medical University
Beijing, Beijing Municipality, China
Xinqiao Hospital of Chongqing
Chongqing, Chongqing Municipality, China
The First People's Hospital of Foshan
Foshan, Guangdong, China
Southern Medical University Zhujiang Hospital
Guangzhou, Guangdong, China
Southern Medical University Nanfang Hospital
Guangzhou, Guangdong, China
Zhongshan City People's Hospital
Zhongshan, Guangdong, China
The Affiliated Hospital of Guizhou Medical University
Guiyang, Guizhou, China
Qiandongnanzhou People's Hospital
Kaili, Guizhou, China
The Fourth Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
The First Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
Kaifeng Central Hospital
Kaifeng, Henan, China
The 989 Hospital of the People's Liberation Army Joint Support Force
Pingdingshan, Henan, China
Shangqiu Third People's Hospital
Shangqiu, Henan, China
Changge people's hospital
Xuchang, Henan, China
Henan Provincial People's Hospital
Zhengzhou, Henan, China
Henan Province Hospital of TCM
Zhengzhou, Henan, China
The Second Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Wuhan University People's Hospital
Wuhan, Hubei, China
The Central Hospital of Wuhan
Wuhan, Hubei, China
Hunan Provincial People's Hospital
Changsha, Hunan, China
Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University)
Changsha, Hunan, China
The First Affiliated Hospital Of University Of South China
Hengyang, Hunan, China
The First Affiliated Hospital of Baotou Medical College
Baotou, Inner Mongolia, China
The Second Affiliated Hospital of Baotou Medical College
Baotou, Inner Mongolia, China
The Second Affiliated Hospital of Inner Mongolia Medical University
Hohhot, Inner Mongolia, China
Jiangsu Provincial People's Hospital
Nanjing, Jiangsu, China
The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
General Hospital of Northern Theater Command
Shenyang, Liaoning, China
The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital
Jinan, Shandong, China
The 960th Hospital of the PLA Joint Logistic Support Force
Zibo, Shandong, China
Bao Ji City People's Hospital（BaoJi Emergency Medical Center）
Baoji, Shanxi, China
Fenyang Hospital of Shanxi Province
Fenyang, Shanxi, China
The First Hospital of Shanxi Medical University
Taiyuan, Shanxi, China
Shanxi Provincial People's Hospital
Taiyuan, Shanxi, China
Sichuan Provincial People's Hospital
Chengdu, Sichuan, China
The First Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China
The First People's Hospital of Yunnan Province
Kunming, Yunnan, China
The First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, China
The First Affiliated Hospital of Ningbo University
Ningbo, Zhejiang, China
Chongqing Western Hospital
Chongqing, China
Liangjiang Hospital of Chongqing Medical University
Chongqing, China