Clinical Research Directory

Inclusion Criteria: * Female aged 18-45 * Diagnosis of sickle cell disease (SS or SB0) * Report of at least 1 vaso-occlusive pain episode per month on average in the previous 6 months * Willing to discontinue any hormonal contraception at the time of enrollment. Washout period of 1 month required for all hormonal contraception prior to enrollment in the study. * Access to a device with text messaging capability * Must be able to read and understand English * Willing to comply with study procedures Exclusion Criteria: * SC Disease * Use of Depo Provera in the past 6 months * Changes to sickle cell medications in the past 3 months * Contraindications to use of Nexplanon device as per clinical standards * Currently pregnant or pregnant within the last month or seeking to become pregnant * Currently breastfeeding