Clinical Research Directory

Inclusion Criteria: * African American * age \>18 years * interested in quitting * smoked \>1 cpd for \>1 years * smoked on \>25 days in the past month * willing to take 6 months of study medication and complete all visits * have a home address and functioning telephone number Exclusion Criteria: * Consistent with contraindications for bupropion: * use of psychoactive medications * history of alcohol or substance abuse within the past year * binge drinking (\>5 drinks on one occasion) \>2 times in the past month * history of seizures or head trauma; history of bulimia or anorexia nervosa * pregnant (as measured by over the counter pregnancy test kit for women of child-bearing age only) or contemplating pregnancy; breast feeding * myocardial infarction in the past 2 months * reported use of opiates, cocaine, or stimulants * unstable diabetes * bupropion is a known inhibitor of the liver enzyme CYP2D6, so those taking drugs known to be higher metabolized by this enzyme (e.g., metoprolol, tamoxifen) will be excluded. * use of stop smoking medications (bupropion, varenicline, nicotine replacement, fluoxetine, clonidine, buspirone, or doxepin) in the past 30 days * planning to move from the Kansas City area in the next year * other smoker in household enrolled in the study.