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The Effect of Remote Ischemic Preconditioning on Myocardial Injury After Noncardiac Surgery
Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University
Summary
This is a multicentre, parallel-group, randomised, sham-controlled, observer blinded trial, assessing the efficacy of remote ischemic preconditioning on preventing myocardial injury after noncardiac surgery.
Official title: The Effect of Remote Ischemic Preconditioning on Myocardial Injury After Noncardiac Surgery in Patients at a High Risk of Cardiac Events
Key Details
Gender
All
Age Range
45 Years - Any
Study Type
INTERVENTIONAL
Enrollment
766
Start Date
2023-05-06
Completion Date
2026-12-31
Last Updated
2024-12-09
Healthy Volunteers
No
Interventions
Remote ischemic preconditioning
Remote ischemic preconditioning will consist of four cycles of 5-minute inflation of an blood pressure cuff on the upper arm to 200 mmHg followed by 5-minute deflation. RIPC will be performed twice, one at approximately 24 hours before anaesthesia and the other at approximately 1 hour before anaesthesia.
Sham-remote ischemic preconditioning
The identical looking cuff will be placed around the upper arm but not actually inflated for 40 minutes. The control device's components and external appearance are identical to that of the RIPC. However, as compared to the RIPC, the blood pressure cuff's line of inflation is disconnected such that the cuff cannot be inflated. Control treatment will be performed twice, one at approximately 24 hours before anaesthesia and the other at approximately 1 hour before anaesthesia.
Locations (1)
The Sixth Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China