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RECRUITING
NCT05737303
PHASE3

Nab-paclitaxel Versus Sb-taxanes As First-Line Treatment in Advanced Ovarian Cancer

Sponsor: Women's Hospital School Of Medicine Zhejiang University

View on ClinicalTrials.gov

Summary

The purpose of this study is to compare the efficacy and safety of nab-paclitaxel with solvent-based taxanes as first-line treatment for patients with advanced primary epithelial ovarian cancer (EOC), primary peritoneal carcinoma or fallopian tube carcinoma.

Official title: Nab-paclitaxel Versus Solvent-based Taxanes As First-Line Treatment for Patients With Advanced Ovarian Cancer

Key Details

Gender

FEMALE

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

538

Start Date

2023-11-27

Completion Date

2027-12-31

Last Updated

2025-02-11

Healthy Volunteers

No

Interventions

DRUG

nab-paclitaxel combined with carboplatin

Nab-Paclitaxel/carboplatin q3weeks Nab-Paclitaxel 260 mg/m² IV followed by carboplatin AUC(area under the curve) 5 IV Day1 Repeat every 21 days x 6 cycles Nab-Paclitaxel/carboplatin weekly Dose-dense Nab-Paclitaxel 100 mg/m2 IV followed by carboplatin AUC(area under the curve)2 IV Davs 1. 8, and 15 ·Repeat every 21 days x 6 cycles Paclitaxel 175 mg/m² IV followed by carboplatin AUC(area under the curve)5 IV Day·1Repeat every 21 days x 6 cycles Paclitaxel weekly/carboplatin weekly Paclitaxel 60 mg/m2 followed by carboplatin AUC(area under the curve)2 IV Days 1.8. and 15: repeat every 21 days 6 cycles (18 weeks)

Locations (11)

Sun Yat-Sen University Cancer Hospital

Guangzhou, Guangdong, China

Qilu Hospital of Shandong University

Ji'nan, Shandong, China

Yaxia Chen

Hangzhou, Zhejiang, China

Sir Run Run Hospital

Hangzhou, Zhejiang, China

The First Affiliated Hospital of Medical College of Zhejiang University

Hangzhou, Zhejiang, China

The Second Affiliated Hospital of Medical College of Zhejiang University

Hangzhou, Zhejiang, China

Zhejiang Cancer Hospital

Hangzhou, Zhejiang, China

Ningbo women's and children's Hospital

Ningbo, Zhejiang, China

The No, 1 People's Hospital of Ningbo

Ningbo, Zhejiang, China

The Second Affiliated Hospital of Wenzhou Medical University

Wenzhou, Zhejiang, China

The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, China