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Nab-paclitaxel Versus Sb-taxanes As First-Line Treatment in Advanced Ovarian Cancer
Sponsor: Women's Hospital School Of Medicine Zhejiang University
Summary
The purpose of this study is to compare the efficacy and safety of nab-paclitaxel with solvent-based taxanes as first-line treatment for patients with advanced primary epithelial ovarian cancer (EOC), primary peritoneal carcinoma or fallopian tube carcinoma.
Official title: Nab-paclitaxel Versus Solvent-based Taxanes As First-Line Treatment for Patients With Advanced Ovarian Cancer
Key Details
Gender
FEMALE
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
538
Start Date
2023-11-27
Completion Date
2027-12-31
Last Updated
2025-02-11
Healthy Volunteers
No
Conditions
Interventions
nab-paclitaxel combined with carboplatin
Nab-Paclitaxel/carboplatin q3weeks Nab-Paclitaxel 260 mg/m² IV followed by carboplatin AUC(area under the curve) 5 IV Day1 Repeat every 21 days x 6 cycles Nab-Paclitaxel/carboplatin weekly Dose-dense Nab-Paclitaxel 100 mg/m2 IV followed by carboplatin AUC(area under the curve)2 IV Davs 1. 8, and 15 ·Repeat every 21 days x 6 cycles Paclitaxel 175 mg/m² IV followed by carboplatin AUC(area under the curve)5 IV Day·1Repeat every 21 days x 6 cycles Paclitaxel weekly/carboplatin weekly Paclitaxel 60 mg/m2 followed by carboplatin AUC(area under the curve)2 IV Days 1.8. and 15: repeat every 21 days 6 cycles (18 weeks)
Locations (11)
Sun Yat-Sen University Cancer Hospital
Guangzhou, Guangdong, China
Qilu Hospital of Shandong University
Ji'nan, Shandong, China
Yaxia Chen
Hangzhou, Zhejiang, China
Sir Run Run Hospital
Hangzhou, Zhejiang, China
The First Affiliated Hospital of Medical College of Zhejiang University
Hangzhou, Zhejiang, China
The Second Affiliated Hospital of Medical College of Zhejiang University
Hangzhou, Zhejiang, China
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China
Ningbo women's and children's Hospital
Ningbo, Zhejiang, China
The No, 1 People's Hospital of Ningbo
Ningbo, Zhejiang, China
The Second Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, China