Clinical Research Directory

Inclusion Criteria: * Aged 18 years to 75 years * Confirmed diagnosis of end-stage renal disease * Standard peritoneal balance test shows rapid peritoneal solute transfer rate, defined as 4 hours D/P creatinine value greater than 0.65 * Be able to comply with the standard peritoneal dialysis treatment at home * Peritoneal dialysis time 3 months and longer * Fully understand the study and have signed the informed consent Exclusion Criteria: * Prepare for kidney transplantation within 3 years * Need combined treatment of hemodialysis * Be allergic to components of peritoneal dialysis fluid * Complicated with severe cardio-cerebrovascular diseases such as congestive heart failure, grade III and above of NYHA classification, acute myocardial infarction within 3 months, malignant arrhythmia requiring treatment, dilated cardiomyopathy, acute cerebral infarction or acute cerebral hemorrhage within 3 months, etc. * Complicated with serious liver diseases, such as cirrhosis or acute liver injury \[Alanine aminotransferase (ALT) or Aspartate aminotransferase (AST) 2 times greater the the normal\] * Active or treated residual malignant tumors, HIV infection * Pregnant or lactating women at childbearing age who disagree to use effective contraceptives during the trial * History of alcohol or drug (illegal drugs) abuse * Unable to continue CAPD due to ultrafiltration failure * Mental retardation or mental illness * Patients who use icodextrin dialysate * Participation in other clinical trials in the past 3 months * Peritonitis in the past 3 months * Other situations decided by the investigator