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Registry Study for Optimal Management of Liver Failure in the Chinese Population
Sponsor: First Affiliated Hospital Xi'an Jiaotong University
Summary
Liver failure is the most severe form of liver damage caused by viral, alcoholic, drug-related and ischemia-reperfusion factors, often combined with extrahepatic organ damage, resulting in a high mortality rate. This study intends to construct a real-world case registry database of inpatients with liver failure based on an electronic clinical data collection system through a multicenter collaborative network to study the clinical characteristics, epidemiology of bacterial and fungal infections, the impact of sarcopenia on clinical prognosis, and optimization of treatment strategies such as antiviral and artificial liver in Chinese inpatients with liver failure. The cohort and experience generated from this study will be used as a support for a series of future studies to focus on clinical issues such as infection, end-stage liver disease combined with organ failure, and early warning of critically ill patients.
Official title: Registry Study for Optimal Management of Liver Failure in the Chinese Population (RESOLVE-C)
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
500
Start Date
2023-01-06
Completion Date
2028-12-30
Last Updated
2023-02-23
Healthy Volunteers
No
Conditions
Interventions
ALF
Acute onset, no history of underlying liver disease, liver failure characterized by degree Ⅱ or above hepatic encephalopathy developed within 2 weeks
SALF
The onset was acute, with no history of underlying liver disease, and clinical manifestations of liver failure appeared between 2 and 26 weeks
ACLF
On the basis of chronic liver disease, the clinical manifestations of acute liver decompensation and liver failure appear in a short period
Locations (14)
First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China
Ankang Central Hospital
Ankang, China
Xiangya Hospital of Central South University
Changsha, China
Hanzhong 3201 Hospital
Hanzhong, China
Qilu Hospital of Shandong University
Jinan, China
First Hospital of Lanzhou University
Lanzhou, China
Weinan Central Hospital
Weinan, China
Air Force Medical University Tangdu Hospital
Xi'an, China
Shaanxi provincial people's hospital
Xi'an, China
The Second Affiliated Hospital of Xi'an Jiaotong University
Xi'an, China
Xi 'an International Medical Center Hospital
Xi'an, China
Xianyang Central Hospital
Xianyang, China
The Affiliated Hospital of Yan'an University
Yanan, China
General Hospital of Ningxia Medical University
Yinchuan, China