Clinical Research Directory

Inclusion Criteria: * Age 18-75 years * Moderate-severe OSA (defined as ODI ≥10 events/hour) via Polysomnography (PSG) or Home Sleep Apnea Study (HSAT) done based on clinical grounds * Excessively sleepy subtype determined by patient-reported symptoms * Willing to accept CPAP therapy * An elevated baseline office BP defined as ≥120 or ≥80 mmHg * Planned PAP (CPAP or bi-level PAP) treatment by treating provider Exclusion Criteria: * Recent changes (within 3 months) to BP medications among those who are on these medications * Unable to apply ABPM cuff * Current use of CPAP or other OSA treatments * Resting, awake SaO2 \<90% or use of home oxygen therapy * New York Heart Association (NYHA) categories III-IV of heart failure * Presence of Cheyne-Stokes Respiration (CSR) in sleep study identified by typical crescendo-decrescendo pattern of respiration with associated apneas and/or hypopneas in the absence of inspiratory flow limitation * Predominantly central sleep apnea (AHI≥15 events/hour, with \>50% central events \[apnea or hypopnea\]) * Life expectancy \<2 years * Pregnancy * Clinical history of chronic kidney disease (Stage 5) requiring dialysis, or renal transplant * Systolic BP \> 180 mmHg