Clinical Research Directory

Inclusion Criteria: 1. Over the age of 18 2. Biopsy-confirmed mucosal head and neck cancer. All histologic malignancies will be included. 3. Patients who have completed primary tumor surgical resection in the following anatomic subsites: 1. oral cavity (oral tongue, floor of mouth, hard palate, buccal mucosa, retromolar trigone, maxillary and mandibular alveolus, lip) 2. oropharynx (soft palate, base of tongue, palatine tonsils) 3. hypopharynx (piriform sinus, post-cricoid, posterior pharyngeal wall) 4. larynx (supraglottic, glottic, subglottic); 4. Patients who have consented to 3D specimen mapping on protocol IRB # 221597 and for whom 3D specimen maps are therefore available. 5. Patients are indicated to receive curative-intent post-operative radiotherapy and intend to receive radiotherapy at Vanderbilt University Medical Center or Vanderbilt Ingram Cancer Center sites in Nashville, Franklin, or Lebanon Exclusion Criteria: 1. Under the age of 18 2. Cutaneous malignancies 3. Characteristics that make the process of informed consent questionable 4. Pregnant women 5. Patients with contraindications to radiotherapy