Clinical Research Directory

Inclusion Criteria: * CT examination revealed adrenal nodules (maximum diameter ≥10mm); * Serum cortisol \> 50nmol/L after 1mg dexamethasone inhibition test (1mg-DST). Exclusion Criteria: * Patients with primary aldosteronism (PA), pheochromocytoma, adrenal metastatic carcinoma, congenital adrenal hyperplasia (CAH), ganglionic neuroma/paraganglioma, schwannoma, adrenal hematoma and those with no definite diagnosis were evaluated by clinical and endocrine function. * Patients with serious underlying diseases (such as liver and kidney failure, acute severe infection, etc.) that may affect the function of the hypothalamic-pituitary-adrenal axis (HPA axis); Pregnancy. * Patients with a history of alcoholism, fatigue, trauma, infection, depression, glucocorticoid use, and other drugs affecting the function of the hypothalamic-pituitary-adrenal axis. * Patients who are not willing to participate in and complete this study refuse to sign the written informed consent for this study.