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RECRUITING
NCT05745987
PHASE4

Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT

Sponsor: McMaster University

View on ClinicalTrials.gov

Summary

A cluster randomized controlled trial to determine if smallpox vaccine reduces secondary cases and symptom severity in persons exposed to mpox.

Official title: SMART (Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster Randomized Controlled Trial)

Key Details

Gender

All

Age Range

2 Years - Any

Study Type

INTERVENTIONAL

Enrollment

3000

Start Date

2024-09-17

Completion Date

2026-12-01

Last Updated

2025-07-06

Healthy Volunteers

Yes

Conditions

Interventions

DRUG

Bavarian Nordic smallpox vaccine

A single dose of the Bavarian Nordic smallpox vaccine will be given at baseline.

DRUG

Typhoid VI Polysaccharide Vaccine Injectable Solution

A single dose of the typhoid vaccine will be given at baseline.

Locations (10)

Catholic University of Bukavu

Kinshasa, Bukavu, Democratic Republic of the Congo

Federal Medical Center

Abuja, Nigeria

University of Abuja Teaching Hospital

Abuja, Nigeria

University of Ibadan

Ibadan, Nigeria

Irrua Specialist Teaching Hospital

Irrua, Nigeria

Aminu Kano Teaching Hospital

Kano, Nigeria

Lagos University Teaching Hospital

Lagos, Nigeria

Niger Delta Teaching Hospital

Okolobiri, Nigeria

University of Port Harcourt Teaching Hospital

Port Harcourt, Nigeria

Makerere University Lung Institute

Kampala, Uganda