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Improving Tissue Repair After Injury in the Muscle-tendon Interface Muscle Tissue Injury
Sponsor: Bispebjerg Hospital
Summary
The study is a 2-week human study where 40 patients who are scheduled to undergo reconstructive knee surgery are randomized to administration of GH or placebo following or without neuromuscular electrical stimulation of hamstring muscles.The overall aim is to determine, the role of muscle connective tissue protein synthesis in muscle injury and repair.
Official title: Regulation of Protein Turnover in Connective Tissue From Muscle and Tendon Following Muscle Tissue Injury
Key Details
Gender
All
Age Range
18 Years - 35 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2023-02-24
Completion Date
2027-09-01
Last Updated
2025-09-24
Healthy Volunteers
Yes
Conditions
Interventions
Electrical stimulation
Experimentally induced muscly injury via. neuromuscular electrical stimulation of the hamstring muscles
Growth hormone (somatropin)
Daily injection of growth hormone
Control (No electrical stimulation, nor growth hormone)
No electrical stimulation, nor growth hormone
Locations (1)
Bispebjerg Hospital
Copenhagen, Denmark