Clinical Research Directory

Inclusion Criteria: * Age \>= 60 ans * Poor prognosis AML defined according to the following criteria:1. For first-line AML:intermediate or unfavorable risk according to ELN 2022 2.for Relapsed AML:regardless of the ELN risk group * ECOG \<= 2 * Patient eligible for intensive chemotherapy * Who provide their written informed consent * Liver workup: transaminases \< 3x normal, bilirubin \< 1.5 X normal * Creatinine clearance \> 60ml/mn * LVEF \>= 50%. Exclusion Criteria: * Patients with FLT3 ITD or TKD mutation * Patients with tuberculosis * Patients with documented active infection with COVID 19 * Patients with hereditary fructose intolerance (HFI) * Uncontrolled infection * Active or past infection with Hep B, C or HIV+ * Not Affiliated with French social security system or no beneficiary from such system * Pregnant women or patients who cannot take contraception ( contraceptive pill, abstinence, unauthorised IUD) in case of fertility. A patient who cannot continue contraception for at least 6 months after the last injection of DARATUMUMAB is not eligible for inclusion. * Breastfeeding women * Minors * Adults under guardianship, curatorship or safeguard of justice * Hypersensitivity to any of the active ingredients or excipients * Patients with significant cardiovascular pathology including any of the following: myocardial infarction within 6 months prior to study entry, unstabilized coronary artery disease, uncontrolled hypertension, congestive heart failure. * Patient with disease requiring systemic immunosuppressive therapy (such as high-dose steroids defined as ≥ 10mg prednisone or equivalent per day) within 4 weeks prior to the 1st scheduled dose of study treatment with the exception of dermocorticoids