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DOCE Study Interaction Between Direct Oral Anticoagulants and Drug-metabolizing Enzyme Inducers
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Summary
Aim of the study is to investigate whether the influence of drugs inducing of CYP 3A4 isoenzyme of CYP450 and P-gp transporter significantly affect plasma levels of DOACs in patients with NVAF and venous thromboembolism
Official title: Interaction Between Direct Oral Anticoagulants and Drug-metabolizing Enzyme Inducers
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
23
Start Date
2021-05-13
Completion Date
2025-05-01
Last Updated
2025-02-27
Healthy Volunteers
No
Interventions
DOACs
outpatients visited in anticoagulation clinics with a prescription of DOAC for atrial fibrillation and venous thromboembolism and concomitant antiepileptic drug will perform a blood draw for measurement of dabigatran, rivaroxaban, apixaban and edoxaban
Locations (1)
Fondazione Policlinico Universitario A.Gemelli IRCCS
Roma, Roma, Italy