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Analgesia-First Sedation in Trauma Patients
Sponsor: MemorialCare Health System
Summary
The study's aim is to ascertain the best approach for providing sedation and pain management for patients who have sustained trauma and are requiring respiratory support from a mechanical ventilator. The common approach to patients who need mechanical ventilation is to provide continuous drips of sedatives and pain medicine and awaken the patient once a day to check the brain functions. Another approach is to provide pain medicine and reserve sedatives for only a short duration when needed. The difference between approaches has not been studied in Trauma patients.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
170
Start Date
2023-04-01
Completion Date
2026-09-01
Last Updated
2025-07-09
Healthy Volunteers
No
Interventions
Analgesia First Sedation Strategy for Mechanically Ventilated (MV) Trauma Subjects
The Intervention is using a sedation strategy for MV trauma that initially targets pain by intermittent boluses followed by an IV drip only if required. Sedatives are limited to agitation management and for a limited duration as needed. This "analgo-sedation" approach differs from the approach of using IV drips of analgesics and sedatives simultaneously and discontinuing both once daily to assess subjects.
Protocol Directed Sedation and Daily Sedation Interruption
The active comparator in this study is using a sedation strategy for MV trauma that uses IV drips of analgesics and sedatives simultaneously and discontinues both once daily to assess subjects.
Locations (1)
Long Beach Memorial Medical Center
Long Beach, California, United States