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A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Participants With Prurigo Nodularis (PN)
Sponsor: Incyte Corporation
Summary
The purpose of this study is to evaluate the safety and tolerability of Ruxolitinib cream in participants with Prurigo Nodularis (PN).
Official title: A Phase 3, Double-Blind, Randomized, Vehicle-Controlled, Efficacy and Safety Study of Ruxolitinib Cream in Participants With Prurigo Nodularis
Key Details
Gender
All
Age Range
18 Years - 99 Years
Study Type
INTERVENTIONAL
Enrollment
204
Start Date
2023-03-10
Completion Date
2025-08-13
Last Updated
2026-08-12
Healthy Volunteers
No
Conditions
Interventions
Ruxolitinib Cream
Ruxolitinib cream 1.5% twice daily (BID) during the vehicle controlled (DBVC)and open label treatment period (OLE).
Vehicle Cream
Ruxolitinib matching vehicle cream 1.5% twice daily (BID) during the vehicle controlled period (DBVC).
Locations (71)
Medical Dermatology Specialists Phoenix
Phoenix, Arizona, United States
Johnson Dermatology
Fort Smith, Arkansas, United States
First Oc Dermatology
Fountain Valley, California, United States
Dermatology Associates Pc
Rockville, Maryland, United States
Clarkston Medical Group
Clarkston, Michigan, United States
Revival Research Institute, Llc Troy
Troy, Michigan, United States
Medisearch Clinical Trials
Saint Joseph, Missouri, United States
Wake Forest University
Winston-Salem, North Carolina, United States
UC Health, Llc
Cincinnati, Ohio, United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
Central Sooner Research
Norman, Oklahoma, United States
Dermatology Associates of Plymouth Meeting
Plymouth Meeting, Pennsylvania, United States
Medical University of South Carolina
Charleston, South Carolina, United States
International Clinical Research Tennessee Llc
Murfreesboro, Tennessee, United States
North Texas Center For Clinical Research Ntccr
Frisco, Texas, United States
Austin Institute For Clinical Research Aicr Pflugerville
Pflugerville, Texas, United States
Center For Clinical Studies
Webster, Texas, United States
Premier Clinical Research
Spokane, Washington, United States
Conexa Investigacion Clinica S.A.
Buenos Aires, Argentina
Cedic Centro de Investigaciones Clinicas
Ciudad Autonoma Buenos Aires, Argentina
Buenos Aires Skin
Ciudad Autonoma Buenos Aires, Argentina
Psoriahue-Medicina Interdisciplinar
Ciudad Autonoma Buenos Aires, Argentina
Centro de Investigaciones Medicas Mar Del Plata
Mar del Plata, Argentina
Fundacion Scherbovsky
Mendoza, Argentina
Instituto de Especialidades de La Salud Rosario
Rosario, Argentina
Centro de Investigaciones Medicas Tucuman
San Miguel de Tucumán, Argentina
Ulb Hospital Erasme
Brussels, Belgium
Cliniques Universitaires Ucl Saint-Luc
Brussels, Belgium
Az Sint-Lucas
Ghent, Belgium
Universitair Ziekenhuis Gent
Ghent, Belgium
Universitair Ziekenhuis (Uz) Leuven
Leuven, Belgium
Centre Hospitalier Universitaire de Liege - Sart Tilman
Liège, Belgium
Chu Ucl Namur de Saint Elisabeth
Namur, Belgium
Beacon Dermatology
Calgary, Alberta, Canada
Simcomed Health Ltd
Barrie, Ontario, Canada
Dermeffects
London, Ontario, Canada
Research Toronto
Toronto, Ontario, Canada
Centre de Recherche Saint-Louis
Québec, Quebec, Canada
Centro Medico Skinmed
Las Condes, Chile
Ciec - Centro Internacional de Estudios Cli-Nicos
Santiago, Chile
Clinical Research Chile Spa.
Valdivia, Chile
Hospital Prive D'Antony
Antony, France
Hospital Morvan
Brest, France
Centre Hospitalier Universitaire de Nantes (Chu de Nantes) - Hotel-Dieu
Nantes, France
University Hospital of Saint Etienne
Saint-Etienne, France
University Medical Center Rwth Aachen
Aachen, Germany
Fachklinik Bad Bentheim Dermatologie
Bad Bentheim, Germany
Universitaetsklinikum Carl Gustav Carus Tu Dresden
Dresden, Germany
Universitatsklinikum Schleswig Holstein
Kiel, Germany
Universitatsmedizin Der Johannes Gutenberg-Universitat Mainz Iii
Mainz, Germany
Universitats-Hautklink Tubingen
Tübingen, Germany
Hautarztpraxis Dr. Med. Matthias Hoffmann
Witten, Germany
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia (Presidio Spedali Civili)
Brescia, Italy
Azienda Ospedaliero Universitaria Policlinico G.Rodolico San Marco
Catania, Italy
Asl 1 Avezzano L'Aquila Sulmona- Ospedale Regionale San Salvatore
Coppito, Italy
Azienda Ospedaliera Universitaria Policlinico 'Federico Ii'
Naples, Italy
Fondazione Policlinico Universitario Agostino Gemelli Irccs
Roma, Italy
Ospedali Riuniti Di Ancona
Torrette, Italy
Amsterdam University Medical Centre
Amsterdam, Netherlands
Bravis Ziekenhuis
Bergen op Zoom, Netherlands
Pratia McM Krakow
Krakow, Poland
ETG LODZ
Lodz, Poland
Kliniczny Szpital Wojewodzki Nr 1
Rzeszów, Poland
Clinical Research Group Sp. Z.O.O
Warsaw, Poland
High-Med Przychodnia Specjalistycza
Warsaw, Poland
Centralny Szpital Kliniczny Mswia
Warsaw, Poland
Hospital General Unviersitario de Alicante
Alicante, Spain
Hospital Universitario Reina Sofia
Córdoba, Spain
Hospital de Manises
Manises, Spain
Hospital Universitario Quironsalud Madrid
Pozuelo de Alarcón, Spain
Complejo Hospitalario Universitario de Santiago
Santiago de Compostela, Spain