Clinical Research Directory

Inclusion Criteria: 1. Patients with maintenance hemodialysis were less than 85 years old and more than 18 years old, both male and female; 2. Regular hemodialysis for more than 3 months, using arteriovenous fistula hemodialysis; 3. Receiving high-throughput dialysis, HDF, and HP according to the conventional treatment regimen; 4. Adequate dialysis (Kt/V\>1.2 within one month); 5. Keep your diet steady. Generally in good condition, have self-awareness, have a good understanding of their own illness and physical condition, and can communicate well with others; 6. Understand and sign the informed consent Exclusion Criteria: 1. Patients with systemic or local severe infection; 2. Patients with severe anemia: Hb\<60g/L; 3. Patients with hypoproteinemia: Alb\<30g/L; 4. Patients with insufficient daily protein intake: nPCR\>1.0g/kg/d; 5. Patients with malignant tumors; 6. Patients with severe cardiovascular and cerebrovascular diseases, such as unstable angina pectoris, malignant hypertension, persistent atrial fibrillation, abnormal Q-wave of electrocardiogram, or patients with acute myocardial infarction, stroke, or coronary stent implantation within 3 months; 7. Patients with severe hematopoietic system diseases, such as aplastic anemia, globin aplastic anemia, thrombocytopenic purpura, etc.; 8. Patients with severe digestive diseases, such as dysphagia, liver insufficiency, active gastrointestinal bleeding, intestinal obstruction, intestinal perforation, or previous subtotal gastrectomy, and other diseases that may affect digestion and absorption; 9. Pregnant women; 10. Participating in other clinical trials within one month or currently; 11. Researchers consider it inappropriate.