Clinical Research Directory

Inclusion Criteria: * Age 18 years and older (no upper age limit defined) * History of chronic migraine as defined by the International Headache Society's International Classification of Headache Disorders (3rd edition). * Response to current preventative therapy with ≥ 50% improvement in the frequency of headache days when compared to baseline * 4 to 14 average number of total headache days per month during peak efficacy of preventative therapy * Ability to understand study procedures and to comply with them for the entire length of the study and use study devices as outlined in protocol. * Patient agrees to maintain a daily electronic headache diary. * Proficient in the use of electronic devices including Apple HomeKit and Apple Watch. - Subjects owns an iPhone with iOS 16 or later operating system installed on iPhone. Apple watch series 8 with watch OS6 or later will be provided by the study. Exclusion Criteria: * Chronic daily headache with no periods of headache freedom. * ≥ 15 average number of headaches days per month during peak efficacy of preventative treatment. * Medication overuse headache as defined by the International Headache Society's International Classification of Headache Disorders (3rd edition). * Daily opioid use for \> 3 months (e.g., hydrocodone, oxycodone, fentanyl patch) or other daily analgesic use for chronic pain disorders (e.g., NSAIDS or acetaminophen). * Inability or unwillingness of individual or legal guardian/representative to give written informed consent.