Clinical Research Directory

Inclusion Criteria: 1. Signed informed consent form before any trial-related processes. 2. Age ≥ 18 years male or female. 3. Have a histologically or cytologically confirmed stage IIIB/IIIC NSCLC that is unresectable and not fit for radical concurrent chemoradiotherapy, or metastatic non-squamous NSCLC (IV). 4. with EGFR mutation confirmed by tumor histology or cytology or hematology prior to EGFR-TKI treatment. 5. EGFR-TKI resistance, confirmed by RECIST v1.1. 6. have adequate organ function. 7. The investigator confirms at least one measurable lesion according to RECIST v1.1. A measurable lesion located in the field of previous radiation therapy or after local treatment may be selected as a target lesion if progression is confirmed. 8. The Eastern Cancer Cooperative Group (ECOG) performance score of 0 or 1. Exclusion Criteria: 1. Squamous cell \> 10%. If small cell types are present, the subject is not eligible for inclusion. 2. Have other driving gene mutations that can obtain effective treatment. 3. Have previously received systemic anti-tumor treatment other than EGFR-TKI for advanced non-squamous NSCLC. 4. Have received systemic steroid therapy or any other form of immunosuppressive therapy within 14 days prior to the first dose of study drugs. 5. Have received EGFR-TKI treatment, within 14 days prior to the first dose of study drugs 6. Anticoagulant or thrombolytic agent within 10 days prior to the first dose of study drugs. 7. Evidence and history of severe bleeding tendency or coagulation dysfunction. 8. The toxicity of previous anti-tumor therapy has not been alleviated. 9. Symptomatic central nervous system metastases (CNS) metastasis and/or cancerous meningitis. 10. Have suffered from the second primary active malignant tumor in the past 5 years.