Clinical Research Directory

Inclusion Criteria: * Women undergoing bilateral nipple-sparing mastectomy (prophylactic or therapeutic) at a single institution * Women receiving implant-based reconstruction (either direct to implant or tissue expander-based implant reconstruction of any size) * Age 18 or older Exclusion Criteria: * Women with history of prior breast surgery given concern for potentially damaged nerves by prior intervention that could impact the procedure and results. Procedures include but are not limited to: prior breast reduction, prior breast augmentation, prior lumpectomy * Pre-operative radiation or anticipated post-operative radiation * Body Mass Index (BMI) \> 30 kg/m2 or patients with macromastia (larger breasts) as these patients frequently require larger implants that will not accommodate the longest nerve graft available (70 mm) * Current tobacco or nicotine use * History of diabetes mellites with a HgbA1c \> 7% due to lower rates of wound healing * History of auto-immune disease * History of allergy, sensitivity, or intolerance to porcine-derived materials * Intraoperatively, patients may have to be excluded if during the mastectomy the lateral nerve targets were severely damaged or removed as part of the mastectomy. While these patients will be excluded from the formal analysis, the investigators will continue to follow them as a subgroup for analysis and comparison. * Men as they infrequently receive bilateral mastectomies due to breast cancer. Male breast cancer is \<1% of all breast malignancies. * Pregnancy as determined by urine pregnancy test on day of surgery