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The Effect of Subclinical Leaflet Thrombosis and Prosthesis Type on Transcatheter Aortic Valve Degeneration (POPular PET TAVI)
Sponsor: St. Antonius Hospital
Summary
A multicentre cross-sectional cohort study to assess the difference in bioprosthetic micro-calcification activity, detected with 18F-NaF PET-CT, as early marker of transcatheter valve degeneration, between patients with vs. without subclinical leaflet thrombosis at five years after TAVI; and between patients with intra-annular vs. supra-annular TAVI prostheses.
Official title: The Effect of Subclinical Leaflet Thrombosis and Prosthesis Type on Transcatheter Aortic Valve Degeneration
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
180
Start Date
2023-11-16
Completion Date
2025-11
Last Updated
2024-04-10
Healthy Volunteers
Not specified
Conditions
Interventions
18F-sodium fluoride Positron Emission Tomography (18F-NaF PET), Cardiac Computed Tomography (CT), Transthoracic Echocardiography (TTE)
Patients undergo a hybrid 18F-NaF-PET CT scan and TTE at five years after TAVI
Locations (4)
Rigshospitalet
Copenhagen, Denmark
St. Antonius Hospital
Nieuwegein, Utrecht, Netherlands
Amsterdam UMC
Amsterdam, Netherlands
University of Edinburgh
Edinburgh, United Kingdom