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Prevention of Post-Operative Nausea and Vomiting With Propofol Infusion
Sponsor: Milton S. Hershey Medical Center
Summary
The purpose of this study is to clarify whether or not a low-dose propofol infusion can effectively prevent postoperative nausea and vomiting (PONV) in patients who have a documented history of PONV and/or motion sickness.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
65
Start Date
2024-02-01
Completion Date
2025-03-12
Last Updated
2026-08-14
Healthy Volunteers
No
Conditions
Interventions
Hybrid anesthesia (propofol + sevoflurane)
General anesthesia maintained with a continuous low-dose propofol infusion (25 mcg/kg/min) combined with sevoflurane. Anesthetic depth was titrated to a bispectral index (BIS) target of 40-60. No other hypnotic or sedative agents were permitted.
Propofol only TIVA
General anesthesia maintained exclusively with intravenous propofol infusion, without the use of volatile anesthetics. Propofol dosing was titrated to maintain a bispectral index (BIS) target of 40-60. No other hypnotic or sedative agents were permitted
Locations (1)
Penn State Health Milton S Hershey Medical Center
Hershey, Pennsylvania, United States