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Vesiculogenesis in Children With GH Deficiency (VESCIGHTP)
Sponsor: Istituto Auxologico Italiano
Summary
The primary objective of the study is to evaluate the size and derivational profile of the extracellular vescicles (EV) generated in children with GH deficiency, undergoing hormone replacement therapy with rhGH. Secondary objectives is to correlate vesiculogenesis with auxometric and biochemical parameters used in clinical-endocrine practice in the evaluation of short stature. The results of the study will provide useful information to more rationally set up the clinical and biochemical follow-up of hormone replacement therapy with rhGH, as well as to understand the molecular and cellular mechanisms underlying the multi-systemic action of GH, the most important anabolic hormone of the human organism.
Official title: Evaluation of Vesiculogenesis in Children With GH Deficiency Undergoing Hormone Replacement Therapy
Key Details
Gender
All
Age Range
5 Years - 15 Years
Study Type
OBSERVATIONAL
Enrollment
10
Start Date
2022-06-24
Completion Date
2025-12-31
Last Updated
2024-10-02
Healthy Volunteers
No
Conditions
Interventions
rhGH
Hormone replacement therapy with rhGH at a dose of 0.025-0.035 mg/kg of body weight per day (or 0.7-1.0 mg/m2 of body surface area per day).
Locations (1)
Istituto Auxologico Italiano IRCCS
Milan, Italy