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The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults
Sponsor: University of Florida
Summary
Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, we will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, and decision-making.
Key Details
Gender
All
Age Range
45 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
45
Start Date
2023-09-12
Completion Date
2026-12
Last Updated
2025-04-24
Healthy Volunteers
Yes
Conditions
Interventions
OxyCODONE 5 mg Oral Tablet
Oxycodone 5mg oral administration
OxyCODONE 2.5 mg Oral Tablet
Oxycodone 2.5mg oral administration
Placebo oxyCODONE Oral Tablet
Oxycodone 0mg (placebo) oral administration
Oxytocin Nasal Spray (48 IU)
Intranasal oxytocin administration (48 IU)
Placebo Oxytocin Nasal Spray
Intranasal oxytocin placebo administration
Locations (1)
University of Florida
Gainesville, Florida, United States