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Screening for Lung Cancer in Subjects With Family History of Lung Cancer
Sponsor: The University of Hong Kong
Summary
Lung cancer can be detected via screening of high-risk individuals, i.e current or ex-heavy smokers, with low-dose computer tomography (LDCT) of thorax. The National Lung Screening Trial in US and the NELSON trial in Europe demonstrated reduction in lung cancer mortality with LDCT screening for lung cancer. In Hong Kong, however, there is a prominence of female never-smokers with lung cancer. There is no identifiable risk factors for non-smokers with lung cancer except family history of lung cancer. The hypothesis is that lung cancer screening for subjects with family history of lung cancer, can detect early lung cancer.
Key Details
Gender
All
Age Range
50 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
1520
Start Date
2023-02-01
Completion Date
2028-05
Last Updated
2026-06-09
Healthy Volunteers
Not specified
Conditions
Interventions
Low dose CT thorax
A multi-detector row CT scanner with minimum section collimation of ≤1 mm and minimum number of data acquisition channels ≥ 16will be employed.
Low dose CT thorax
Control subjects will also proceed to CT thorax, and outcome measures be compared to subjects
Locations (1)
University of Hong Kong
Hong Kong, Hong Kong, Hong Kong