Clinical Research Directory
Browse clinical research sites, groups, and studies.
Improved Diagnosis of Ovarian Cancer by Use of Circulating Tumor DNA as a Biomarker
Sponsor: University of Aarhus
Summary
This project investigates circulating tumor DNA (ctDNA) in patients with suspected ovarian malignancy. We hypothesize that measurement of ctDNA in women with suspected ovarian cancer can improve the diagnostic efficiency for preoperative differentiation between benign and malignant masses. Specifically, we hope to determine the diagnostic efficiency of ctDNA alone and ctDNA in combination with imaging modalities (ultrasonography, MRI, PET-CT) and CA 125 for preoperative differentiation between benign and malignant adnexal masses. Based on this, we hope to develop an improved diagnostic algorithm. The mutational profile and relation to tumour type, stage, treatment response and prognosis will be explored. Analyses of blood and tissue samples will be used to examine the disease development and biology. Blood samples, tumour tissue and data on imaging modalities as well as CA 125 will be collected prospectively in consecutive women referred to Aarhus University Hospital.
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2022-07-01
Completion Date
2029-05-04
Last Updated
2024-05-09
Healthy Volunteers
No
Locations (1)
Department of Gynaecology and Obstetrics, Aarhus University Hospital
Aarhus, Denmark