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RECRUITING
NCT05764733
PHASE4

Bone, Exercise, Alendronate, and Caloric Restriction

Sponsor: Wake Forest University Health Sciences

View on ClinicalTrials.gov

Summary

The purpose of this research is to identify strategies that minimize bone loss that occurs when older adults lose weight. Participation in this research will involve up to nine assessment visits and last up to two years.

Official title: The Bone, Exercise, Alendronate, and Caloric Restriction Trial

Key Details

Gender

All

Age Range

60 Years - Any

Study Type

INTERVENTIONAL

Enrollment

900

Start Date

2023-06-08

Completion Date

2027-09

Last Updated

2025-12-17

Healthy Volunteers

No

Conditions

Interventions

DRUG

Bisphosphonate

Medicine used to treat bone problems, called osteopenia or osteoporosis.

BEHAVIORAL

Resistance Training/Bone-Loading Exercise

Exercise in small groups three days per week under the supervision of exercise physiologists. Heart rate and blood pressure will be measured before and after each session and participants will warm-up by walking or cycling for five minutes at a slow pace. All RT exercises will be conducted on machines which accommodate different body sizes and allow small increments in resistance, both important considerations for low functioning older adults with obesity.

OTHER

Placebo

Capsules identical to the active alendronate capsules without any active ingredients with the same dosing and follow up as BIS treatment group.

Locations (2)

University of Colorado Anschutz Medical Campus

Aurora, Colorado, United States

Atrium Health Wake Forest Baptist Medical Center

Winston-Salem, North Carolina, United States