Clinical Research Directory
Browse clinical research sites, groups, and studies.
Triple Therapy of Dexamethasone, Palonosetron, and Fosaprepitant As PONV Prevention
Sponsor: Samsung Medical Center
Summary
As a preventive for postoperative nausea and vomiting in patients undergoing laparoscopic gynecological surgery, the investigators shall investigate the efficacy of the triple therapy of dexamethasone, palonosetron, and fosaprepitant comparing to dual therapy of dexamethasone and palonosetron.
Official title: Comparison of Dual Therapy of Dexamethasone and Palonosetron and Triple Therapy of Dexamethasone, Palonosetron, Fosaprepitant for Postoperative Nausea and Vomiting Prevention: a Randomized Controlled Trial
Key Details
Gender
FEMALE
Age Range
19 Years - 49 Years
Study Type
INTERVENTIONAL
Enrollment
144
Start Date
2023-08-18
Completion Date
2025-12
Last Updated
2025-03-30
Healthy Volunteers
No
Interventions
fosaprepitant
The subject is then moved to the operating room and undergoes induction of general anesthesia. After the induction of anesthesia, 5 mg of dexamethasone and 0.075 mg of palonosetron are intravenously administered. In the experimental group, the subject is then moved to the operating room and undergoes induction of general anesthesia. After the induction of anesthesia, 5 mg of dexamethasone and 0.075 mg of palonosetron are intravenously administered.
normal saline
On the day of surgery, in the preoperative holding area, the principal investigator administers the study drug to the participants. During the study drug administration period, the principal investigator observes the presence of specific symptoms and abnormalities at the injection site of participants. In the case of the control group, the study drug is 150 ml of normal saline, which is visually indistinguishable from the dilute solution of the fosaprepitant, administered over 30 minutes.
Locations (1)
Samsung Medical Center
Seoul, Seoul, South Korea