Clinical Research Directory

Inclusion Criteria: * Age \>18 years * Atherosclerosis (neurovascular, cardiac or peripheral) with an indication to start a high intensity statin-therapy (equivalent to 40mg of atorvastatin or 20mg of rosuvastatin; start of statin therapy +/- 10 days of enrolment) * Statin naivety * LDL-C \>100 mg/dl. No older than 21 days Exclusion Criteria: * Inability to take medication independently or to use the mediteo m+ app independently (e.g. people in need of care, people with dementia) * Patient has no own smartphone (no device provided for this study) * Prior drug therapy to lower LDL-C within the last 30 days * Active cancer (defined as a diagnosis of cancer within 6 months before enrolment, any treatment for cancer within the previous 6 months, or recurrent or metastatic cancer) or other severe concomitant disease with a life expectancy of \<6 months * Use of a digital therapy management application (including mediteo or mediteo m+) within the last month * Participation in another interventional trial * Pregnancy * Inability or unwillingness to provide informed consent