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Multi-parametric MRI in Patients Suspected for Muscle Invasive Bladder Cancer: a New Local Staging Paradigm
Sponsor: Radboud University Medical Center
Summary
A two-arm multicenter randomised controlled trial, comparing progression free survival, time to definitive treatment and cost-effectiveness of the standard of care (TURBT) and mpMRI followed by same-day cystoscopic bladder biopsy for diagnosis of patients with suspicion of muscle-invasive bladder cancer.
Official title: Multi-parametric MRI in Patients Suspected for Muscle Invasive Bladder Cancer: a New Local Staging Paradigm (BladParadigm)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
360
Start Date
2023-12-06
Completion Date
2031-06
Last Updated
2026-01-08
Healthy Volunteers
No
Interventions
mpMRI plus a same-day cystoscopic bladder biopsy
mpMRI plus a same-day cystoscopic bladder biopsy
TURBT
Transurethral resection of the bladder tumor, blood withdrawal shortly before and after TURBT
Locations (19)
Jeroen Bosch ziekenhuis
's-Hertogenbosch, Netherlands
Ziekenhuisgroep Twente
Almelo, Netherlands
Meander MC
Amersfoort, Netherlands
Amsterdam UMC, location AMC
Amsterdam, Netherlands
Amsterdam UMC, location VUmc
Amsterdam, Netherlands
Antoni van Leeuwenhoek - Netherlands Cancer Institute
Amsterdam, Netherlands
OLVG
Amsterdam, Netherlands
Rijnstate ziekenhuis
Arnhem, Netherlands
Maasziekenhuis Pantein
Boxmeer, Netherlands
Ziekenhuis Gelderse Vallei
Ede, Netherlands
Treant
Emmen, Netherlands
Medisch Spectrum Twente
Enschede, Netherlands
St. Antonius ziekenhuis
Nieuwegein, Netherlands
Canisius Wilhelmina Ziekenhuis
Nijmegen, Netherlands
Radboud university medical center
Nijmegen, Netherlands
Erasmus Medical Center
Rotterdam, Netherlands
Bernhoven ziekenhuis
Uden, Netherlands
University Medical Center Utrecht
Utrecht, Netherlands
VieCuri medisch centrum
Venlo, Netherlands